Invited Review Perspectives on endothelial-to-mesenchymal transition: potential contribution to vascular remodeling in chronic pulmonary hypertension
نویسندگان
چکیده
Enrique Arciniegas, Maria G. Frid, Ivor S. Douglas, and Kurt R. Stenmark Laboratorio de Microscopia Electrónica, Servicio Autónomo Instituto de Biomedicina, Facultad de Medicina, Universidad Central de Venezuela, Caracas, Venezuela; Pediatric Critical Care Medicine, Developmental Lung Biology Laboratory and Cardiovascular Pulmonary Research, University of Colorado Health Sciences Center, Denver; and Pulmonary Sciences and Critical Care Medicine, Denver Health and University of Colorado Health Sciences Center, Denver, Colorado
منابع مشابه
Perspectives on endothelial-to-mesenchymal transition: potential contribution to vascular remodeling in chronic pulmonary hypertension.
All forms of pulmonary hypertension are characterized by structural changes in pulmonary arteries. Increased numbers of cells expressing alpha-smooth muscle (alpha-SM) actin is a nearly universal finding in the remodeled artery. Traditionally, it was assumed that resident smooth muscle cells were the exclusive source of these newly appearing alpha-SM actin-expressing cells. However, rapidly eme...
متن کاملActivation of Nrf2 Attenuates Pulmonary Vascular Remodeling via Inhibiting Endothelial-to-Mesenchymal Transition: an Insight from a Plant Polyphenol
The endothelial-to-mesenchymal transition (EndMT) has been demonstrated to be involved in pulmonary vascular remodeling. It is partly attributed to oxidative and inflammatory stresses in endothelial cells. In current study, we conducted a series of experiments to clarify the effect of salvianolic acid A (SAA), a kind of polyphenol compound, in the process of EndMT in human pulmonary arterial en...
متن کاملEffect of thoracic epidural blockade on hypoxia-induced pulmonary arterial hypertension in rats
Objective(s): The present study was aimed to investigate the influence of thoracic epidural blockade on hypoxia-induced pulmonary hypertension in rats. Materials and Methods: Forty eight Wistar rats were randomly divided into 4 equal groups, named normoxia hypoxia hypoxia/ ropivacaine and hypoxia/saline. Animals were placed in a hypoxia chamber and instrumented with epidural catheters at the t...
متن کاملMechanisms of structural remodeling in chronic pulmonary hypertension.
1. Explain the physiologic consequences of structural remodeling in chronic pulmonary hypertension. 2. Describe the two primary components of the structural changes that occur in the pulmonary vascular wall during chronic pulmonary hypertension. 3. List the substances produced by endothelial cells that are affected by hypoxia. 4. Describe the potential consequences of changes in hemodynamic str...
متن کاملThe role of inflammation in hypoxic pulmonary hypertension: from cellular mechanisms to clinical phenotypes.
Hypoxic pulmonary hypertension (PH) comprises a heterogeneous group of diseases sharing the common feature of chronic hypoxia-induced pulmonary vascular remodeling. The disease is usually characterized by mild to moderate pulmonary vascular remodeling that is largely thought to be reversible compared with the progressive irreversible disease seen in World Health Organization (WHO) group I disea...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2007